Wychimicin A

Wychimicin A is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin A shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC50=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC50=0.125-0.25 μg/mL) [1][2].

C47H60ClNO11

850.43

CC1=CC(Cl)=C(C(C(N[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@]([H])(C/C=C/C3[C@@]4([C@]5([C@]([H])(C=C3CC)[C@H]([C@H](C[C@@H]5C)O)O)[H])C)/C(C)=C/[C@H]6[C@]7(C[C@@H](C=C6)C)C(O)=C(C(O7)=O)C4=O)C)=O)=C1O)C

Bacterial

10 mM in DMSO

Room temperature