XL-418 [CAS 871343-09-8]

XL-418 is an orally active dual Akt and p70S6K inhibitor with IC50s of 1 nM for Akt1 and 2 nM for p70S6K. XL-418 inhibits the phosphorylation of ribosomal protein S6 and GSK3β. XL-418 can be used for the study of prostate carcinoma and breast cancer[1].

[871343-09-8]

C26H32BrF3N8O

609.48

O=C(C1=CC(NCCN2CCCC2)=C(C)C(N3CCN(C4=C5C(NN=C5Br)=NC=N4)CC3)=C1)CCC(F)(F)F

Akt; GSK-3; Ribosomal S6 Kinase (RSK)

Akt1; GSK-3β; p70S6K

Room temperature