XSJ110 [CAS 203923-65-3]

XSJ110 is a potent irreversible topoisomerase I (Topo I) inhibitor with an IC50 value of 0.133 μM. XSJ110 blocks DNA topoisomerization, induces DNA double-strand breaks, and triggers cell cycle arrest at G0/G1 phase, inducing tumor cell apoptosis. XSJ110 is promising for research of ampullary carcinoma (AC) [1].

[203923-65-3]

C23H20N2O5

404.42

CCC(C1=C2C(C(N3C2)=CC([C@@](O)(CC)C(OC4)=O)=C4C3=O)=NC5=CC=CC=C51)=O

Apoptosis; Topoisomerase

Topo I

Room temperature