XY-06-007 [CAS 2757045-94-4]

XY-06-007 is a selective and potent bump-and-hole (B&H) -PROTAC BRD4BD1L94V degrader. XY-06-007 shows a DC50, 6 h of 10 nM against BRD4BD1L94V with no degradation of off-targets. XY-06-007 demonstrates suitable pharmacokinetics for in vivo studies[1].

[2757045-94-4]

C41H41ClN8O8

809.27

ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C=C(C=C4)OC)C)[C@H](C(NCCCCCNC(COC5=C6C(C(N(C6=O)C7C(NC(CC7)=O)=O)=O)=CC=C5)=O)=O)C)C=C1

Epigenetic Reader Domain; PROTACs

Cereblon

98.9

10 mM in DMSO

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature