XZ338

XZ338 is a highly selective degrader targeting BCL-XL. XZ338 does not degrade BCL-2. XZ338 inhibits MOLT-4 cells with a IC50 value of 3.7 nM. XZ338 has anti-proliferative activity. XZ338 can be used for anti-cancer study. (Target protein ligand: HY-19741; E3 ligase: HY-112078; linker: HY-172799; E3+liner: HY-172800).

C69H83N11O8S3

1290.66

O=C(NC1=NC2=CC=CC=C2S1)C3=CC=CC4=C3CN(C5=CC=C(C6=C(C)N(CC7(C[C@H]8C9)C[C@H]9C[C@H](C8)C7)N=C6)C(C(NS(CCCCCCCC(N[C@@H](C(C)(C)C)C(N%10[C@H](C(N[C@@H](C)C%11=CC=C(C%12=C(C)N=CS%12)C=C%11)=O)C[C@@H](O)C%10)=O)=O)(=O)=O)=O)=N5)CC4

Bcl-2 Family

Room temperature