Y-29794 [CAS 129184-48-1]

Y-29794 is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 penetrates the brain-blood barrier (BBB) [1][2].

[129184-48-1]

C23H34N2OS2

418.66

O=C(C1=C(SCCCCCCCCN(C)C)N=C(C(C)C)C=C1)C2=CC=CS2

Prolyl Endopeptidase (PREP)

PREP

Room temperature