YCH2823

YCH2823 is an inhibitor of USP7 (IC50 = 49.6 nM; Kd = 0.117 μM) . YCH2823 shows significant efficacy in inhibiting TP53 wild-type and mutant tumors, with approximately 5-fold higher potency than FT671. YCH2823 induce apoptosis. YCH2823 synergistic effects with mTOR inhibitors[1].

C29H32N4O4

500.59

COC1=CC=C(C=C1)N2C=CC3=C2N=CN(C3=O)CC4(CCN(CC4)C(C[C@H](C5=CC=CC=C5)C)=O)O

Apoptosis; Deubiquitinase

USP7

10mM

99.87

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature