YF-452 [CAS 1951466-83-3]

YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) . YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research[1].

[1951466-83-3]

C24H26BrN3O

452.39

BrC1=CC=C(CN(C2=C3C=CC=C2)C4=C3CCN(C4)C(CN5CCCC5)=O)C=C1

VEGFR

VEGFR2/KDR/Flk-1

10 mM in DMSO

Room temperature