YH-0623

YH-0623 is an orally active mitochondrial RNA polymerase (POLRMT) inhibitor (IC50 = 50.48 nM, Nanoluciferase Bioluminescence Resonance Energy Transfer (NanoBRET) assay) . YH-0623 exhibits antiproliferative effects on 22Rv1 cells by reducing the expression of mitochondrial-related genes. YH-0623 inhibits 22Rv1 cell growth, colony formation, and the expression of OXPHOS-related proteins. YH-0623 significantly inhibits tumor growth in a prostate cancer xenograft mouse model. YH-0623 is indicated for prostate cancer research[1].

C25H25FN2O4

436.48

O=C([C@H](OC1=CC2=NC=CC(C3=CC=CC=C3C)=C2C=C1F)C)N4CCC[C@@H](C4)C(O)=O

DNA/RNA Synthesis; Mitochondrial Metabolism; Oxidative Phosphorylation; PDGFR

Room temperature