YJ9069

YJ9069 is a selective CDK12/CDK13 PROTAC degrader with an IC50 of 22.22 nM for in VCaP cells. CDK12/13 degradation rapidly triggers gene-length-dependent transcriptional elongation defects, leading to DNA damage and cell-cycle arrest. YJ9069 effectively inhibits proliferation in subsets of prostate cancer cells and significantly suppresses prostate tumor growth. (Pink: CDK12/CDK13 degradation agent ; Black: Linker (HY-W015967) ; Blue: ligand for E3 ligase (HY-103596) ).

C46H46N10O7

850.92

O=C(NCC1=CC=CC=C1)N(C2=CN=C(N3CCN(C(COC4=C5C(C(N(C6CCC(NC6=O)=O)C5=O)=O)=CC=C4)=O)CC3)C=C2)[C@H](CC7)CC[C@@H]7NC8=NC=C9C(C=CC=C9)=N8

CDK; DNA/RNA Synthesis; PROTACs

CDK12; CDK13

97.63

DMSO : ≥ 50 mg/mL

-20°C (Powder, sealed storage, away from moisture and light)

Blue Ice