YM-53601 free base [CAS 182959-28-0]

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SKU:QM-0000076

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Description
YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo[1]. YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent[2]. YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation[3].
CAS Number
[182959-28-0]
Molecular Formula
C21H21FN2O
Molecular Weight
336.4
Smiles
F/C(COC1=CC(NC2=C3C=CC=C2)=C3C=C1)=C4CN5CCC/4CC5
Target
Farnesyl Transferase; HCV
Solubility
10 mM in DMSO
Shipping Conditions
Room temperature
Hazard Statement
H302-H315-H319-H335
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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YM-53601 free base is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.