YN14 (mixture of diastereomers) [CAS 3053689-54-3]
YN14 (mixture of diastereomers) [CAS 3053689-54-3]
SKU:QM-0007645
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Product Details
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Description
YN14 mixture of diastereomers is the diastereomers of YN14. YN14 is a KRASG12C proteolysis targeting chimera (PROTAC). YN14 is highly potent and selective KRASG12C degrader and induces a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (ΔG). YN14 has antiproliferative effects and significantly inhibits KRASG12C-mutant cancer cell growth[1].
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CAS Number
[3053689-54-3]
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Molecular Formula
C62H75F2N11O7S
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Molecular Weight
1156.39
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Smiles
O=C1N(C2=C(N=CC=C2C)C(C)C)C3=NC(C4=C(C=CC=C4F)OCC5CCN(CC5)CCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)=C(F)C=C3C(N9[C@H](CN(CC9)C(C=C)=O)C)=N1
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Target
PROTACs
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Shipping Conditions
Room temperature
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YN14 (mixture of diastereomers) [CAS 3053689-54-3]
YN14 (mixture of diastereomers) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.