YTHDF2-IN-1

YTHDF2-IN-1 (Compound CK-75) is the inhibitor for YT521-B homology domain family 2 YTHDF2 (Kd=26.2 μM), that blocks the interaction between YTHDF2 and m6A RNA. YTHDF2-IN-1 inhibits the colony formation of JAR cells, exhibits antiproliferative activity in a variety of cancer cells (IC50 in micromolar levels), arrests the cell cycle at G0/G1 phase, induces apoptosis in K562[1].

C21H14N2O4

358.35

O=C(O)C1=CC=C(N2N=CC(C(C3=C4C=CC=CC4=CC=C3O)=O)=C2)C=C1

Apoptosis; YTHDF

YTHDF2

99.42

DMSO : 50 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature