YTHu78

YTHu78 is a KDM5B PROTAC-type degrader. YTHu78 induces KDM5B degradation via the ubiquitin-proteasome system and triggers apoptosis in MV-4-11 and MM.1S cell lines. YTHu78 exhibits significant antiproliferative activity against a variety of hematological cancer cell lines and can be used to study hematological cancers. (Pink: KDM5B ligand: ; Blue: Thalidomide: (HY-14658), Black + Pink: KDM5B ligand + linker: (HY-175145) ).

C33H28N8O6

632.63

O=C1NC(OC2=CN(CC3=CC=C(CCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)N=C2)=NC7=CN=CC=C71

Apoptosis; Caspase; Histone Demethylase; PARP; PROTACs

Caspase 3; Cereblon; KDM5

Room temperature