Zaloglanstat [CAS 1513852-12-4]
Zaloglanstat [CAS 1513852-12-4]
SKU:QM-0146772-01
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Product Details
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Description
Zaloglanstat (ISC-27864; GRC-27864) is a selective, orally active microsomal mPGES-1 inhibitor. Zaloglanstat has an IC50 of 5 nM for human mPGES-1 without significant inhibitory effect on COX-1/2 (IC50 >10 μM) . Zaloglanstat blocks the conversion of arachidonic acid metabolite prostaglandin PGH2 to prostaglandin PGE2, thereby inhibiting inflammation-related PGE2 overproduction and reducing inflammatory responses and pain. Zaloglanstat inhibits IL-1β-induced PGE2 release in A549 cells and human synovial fibroblasts in vitro. Zaloglanstat inhibits PGE2 release in pig and dog whole blood with IC50s ??of 161 nM and 154 nM, respectively. Zaloglanstat can be used in the study of asthma, osteoarthritis, and neurodegenerative diseases[1][2][3].
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CAS Number
[1513852-12-4]
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Molecular Formula
C21H20ClF3N4O2
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Molecular Weight
452.86
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Smiles
O=C1NC(C2=C(Cl)C=CC(CNC(C(C)(C)C)=O)=C2)=NN1C3=CC=C(C(F)(F)F)C=C3
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Target
Collagen; COX; PGE synthase
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Purity
98.5
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Solubility
DMSO : 250 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Zaloglanstat [CAS 1513852-12-4]
Zaloglanstat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.