ZDWX-25 [CAS 2668297-70-7]

ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC50 value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer's disease[1].

[2668297-70-7]

C17H15N3O3

309.32

COC(C1=CC=C2C(NC3=C(N=CC=C23)NC(C4CC4)=O)=C1)=O

GSK-3

GSK-3β

10 mM in DMSO

Room temperature