ZG297 [CAS 2999673-52-6]

ZG297 is an agonist for Staphylococcus aureus ClpP (SaClpP) with an EC50 of 0.26 μM. ZG297 degrades SaFtsZ, inhibits the bacterial cell division, thereby exhibiting antistaphylococcal activity, that inhibits S. aureus 8325-4 strains and MRSA strains with MIC of 0.063-256 μg/mL. ZG297 exhibits anti-infectious efficacy in mouse models[1].

[2999673-52-6]

C31H35F3N4O3

568.63

FC(F)(F)CCCNC(N1[C@](CN(CC2=CC(C=CC=C3)=C3C4=C2C=CC=C4)C([C@@H]5[C@H](CC)C)=O)([H])N5C(CC1)=O)=O

Antibiotic; Bacterial

Room temperature