ZIKV-IN-5

ZIKV-IN-5 (compound 5c) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=0.71 μM) . ZIKV-IN-5 effectively inhibits the activity of ZIKV NS5 MTase[1].

C36H45NO4Si

583.83

O=C1OCC=C1/C=C/[C@@H]2C(CC[C@]3([H])[C@](C)(CO[Si](C4=CC=CC=C4)(C(C)(C)C)C5=CC=CC=C5)/C(CC[C@@]23C)=N/O)=C

Virus Protease

10 mM in DMSO

Room temperature