Zinc Protoporphyrin [CAS 15442-64-5]

Zinc Protoporphyrin (Zn (II) -protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc Protoporphyrin regulates expression of HO-1 at the transcriptional level. The effect of Zinc Protoporphyrin on HO-1 expression is controversial. It was shown to induce HO-1 expression in some cells, but suppress it in others. Zinc Protoporphyrin is used as a screening marker of iron deficiency in vivo. Zinc Protoporphyrin has anti-cancer activity[1][2][3][4][5].

[15442-64-5]

C34H32N4O4Zn

626.02

OC(CCC1=C(C=C2[N]3=C4C(C)=C2CCC(O)=O)[N-]([Zn+2]35[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O

Apoptosis; Endogenous Metabolite; Reactive Oxygen Species (ROS)

Human Endogenous Metabolite

10mM

99.87

DMSO : 20.59 mg/mL (ultrasonic)

-20°C (Powder, sealed storage, away from moisture)

Blue Ice

H302, H315, H319, H335

H302, H315, H319, H335