ZIP14-IN-1 [CAS 1048-17-5]

ZIP 14-IN-1 (PPTD) is a selective and orally active ZIP14 inhibitor. ZIP 14-IN-1 inhibits ZIP14 while sparing ZIP8 (SLC39A8) . ZIP 14-IN-1 efficiently blocks ZIP14-mediated uptake of multiple divalent metals (zinc, iron, manganese and cadmium) . ZIP 14-IN-1 binds to a pocket formed at the dimer interface of ZIP14, obstructing the metal transport pathway. ZIP 14-IN-1 effectively reverses the consequent elevation of reactive oxygen species (ROS) and lipid peroxidation, attenuating metal-induced cytotoxicity. ZIP 14-IN-1 can be uses for cancer cachexia research[1].

[1048-17-5]

C21H25N3O

335.44

O=C1NCN(C2=CC=CC=C2)C13CCN(CCC4=CC=CC=C4)CC3

Ferroptosis; Reactive Oxygen Species (ROS)

Room temperature