Ziptide [CAS 518069-98-2]

Ziptide is a substrate for MAPK activated protein kinase 2 (MAPKAPK2, Km = 5 μM), MAPKAPK3 (Km = 30 μM), PARK (Km = 40 μM), checkpoint kinase 1 (Chk1, Km = 5 μM), AMP-activated protein kinase (AMPK, Km = 75 μM), and calcium/calmodulin-dependent protein kinase II (CamKII, Km = 300 μM) [1].

[518069-98-2]

C65H109N19O19

1460.68

O=C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N2[C@@H](CCC2)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N

AMPK; Checkpoint Kinase (Chk) ; MAPKAPK2 (MK2)

10 mM in DMSO

Room temperature