(-) -ZK 216348

(-) -ZK 216348 is the enantiomer of (+) -ZK 216348. (+) -ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist with an IC50 of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC50s of 20.4 nM and 79.9 nM, respectively. ZK 216348 has antiinflammatory activity similar to Prednisolone and induces less transactivation-mediated side effects[1][2].

C24H23F3N2O5

476.45

O=C1C2=CC=C(C=C2C(C)=NO1)NC(C(C(F)(F)F)(O)CC(C)(C3=C4C(CCO4)=CC=C3)C)=O

Glucocorticoid Receptor

99.59

DMSO : ≥ 140 mg/mL

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature