ZLN024 [CAS 723249-01-2]

ZLN024 is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 μM, 0.95 μM, 1.1 μM and 0.13 μM, respectively.

[723249-01-2]

C13H13BrN2OS

325.22

CC1=CC=C(OCCSC2=NC=CC=N2)C(Br)=C1

AMPK

AMPK α1β1γ1; AMPK α1β2γ1; AMPK α2β1γ1; AMPK α2β2γ1

10 mM in DMSO

Room temperature

H302-H315-H318-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501