ZLWT-37 [CAS 2813347-44-1]

ZLWT-37 is a potent, orally active CDKs inhibitor with IC50 values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells[1].

[2813347-44-1]

C26H30ClN5O

464

N[C@H]1CCN(C1)C2=C3CCCCC3=NC4=C2C=C(C=C4)C5=CC=NC(NC(C6CC6)=O)=C5.Cl

Apoptosis; CDK

CDK2; CDK9

10 mM in DMSO

Room temperature