ZMF-10 [CAS 2415295-37-1]

ZMF-10 is a highly potent PAK1 inhibitor, with IC50s of 174 nM, 1.038 μM and 1.372 μM for PAK1, PAK2 and PAK3, respectively. ZMF-10 can inhibit PAK1 activity to affect PAK1-regulated apoptosis, ER-Stress and migration in MDA-MB-231 cells. ZMF-10 can be used for researching anticancer[1].

[2415295-37-1]

C19H17F6N7O

473.37

O=C(NC1CCN(CC1)C2=C3C=NNC3=NC=N2)NC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4

Apoptosis; PAK

PAK1; PAK2; PAK3

10 mM in DMSO

Room temperature