ZMF-23

ZMF-23 is a PAK1/HDAC6 dual inhibitor. ZMF-23 inhibits PAK1 and HDAC6 regulated aerobic glycolysis and migration. ZMF-23 induces TNF-α-regulated necroptosis, and further enhances apoptosis. ZMF-23 inhibits the Warburg effect and cell migration. ZMF-23 can be used for research of triple-negative breast cancer (TNBC) [1].

C22H23Cl2N5O3

476.36

ClC1=CC(Cl)=CC=C1C2=CC3=CN=C(NC4CC4)N=C3N(CCCCCC(NO)=O)C2=O

HDAC; PAK

10 mM in DMSO

Room temperature