Zomiradomide [CAS 2655656-99-6]

Zomiradomide is an orally active PROTAC degrader for IRAK4 (DC50=6 nM), thereby inhibiting the NF-κB signaling pathway. Zomiradomide acts also as a molecular glue, recruiting Ikaros and Aiolos, and mediating their degradation (DC50 for Ikaros is 1 nM), thereby activating the type I IFN signaling pathway[1][2][3]. (Pink: target protein ligand PROTAC IRAK4 ligand-5 , Blue: E3 ligase ligand Thalidomide-4-Br (HY-W039116), Black: linker (HY-168313) )

[2655656-99-6]

C45H48F3N7O6S

871.97

O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(NCCC(C4)CC4(C5)CN5C[C@H]6CC[C@H](C(SC7=C8)=NC7=CC(C(C)(O)C)=C8NC(C9=CC=CC(C(F)(F)F)=N9)=O)CC6)=C3C1=O

IFNAR; IRAK; NF-κB; PROTACs

95.43

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature