ZX782

ZX782 is a Hty-type PROTAC targeting GPX4 and a ferroptosis inducer, which induces GPX4 degradation and significantly increases lipid ROS accumulation in HT1080 cells. ZX782 can be used to treat AD by reducing the size and/or number of brain amyloid plaques and by inhibiting the spread of IL-1beta-positive microglial-like cells around amyloid plaques. ZX782 is labeled with hydrophobic benzyl alcohol (HBA) and appears bright blue under acidic conditions, which can be used for quantitative determination[1]. ZX782 is composed of target protein ligand (red part) ML-210 , PROTAC linker (black part) Bromo-PEG2-CH2-Boc (HY-141371) and Hty molecule (blue part) Adamantan-1-ylmethanamine (HY-W037848). The conjugate consisting of Hyt and linker parts is Adamantan-C-amide-PEG2-C-Br (HY-161974), and the activity control of the target protein ligand is Hydroxyl-ML-210 (HY-161973).

C39H48ClN5O8

750.28

O=C(C1=NOC(C)=C1[N+]([O-])=O)N2CCN(C(C3=CC=C(OCCOCCOCC(NCC4(C[C@@H](C5)C6)C[C@@H]6C[C@@H]5C4)=O)C=C3)C7=CC=C(Cl)C=C7)CC2

Ferroptosis; Glutathione Peroxidase; PROTACs

GPX4

Room temperature