ZXH-4-130 [CAS 2711006-66-3]

ZXH-4-130 is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC) [1].

[2711006-66-3]

C46H58N6O9S

871.05

O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCCOC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

PROTACs

Von Hippel-Lindau (VHL)

10 mM in DMSO

Room temperature