1,2,3,6-Tetragalloylglucose [CAS 79886-50-3]
1,2,3,6-Tetragalloylglucose [CAS 79886-50-3]
SKU:QM-0003693-01
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Product Details
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Description
1,2,3,6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase UGT1A1, targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 μM and 4.31 μM, respectively, and binds to UGT1A1 with Ki of 3.55 μM. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease[1][2][3].
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CAS Number
[79886-50-3]
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Molecular Formula
C34H28O22
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Molecular Weight
788.57
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Smiles
O=C(C1=CC(O)=C(O)C(O)=C1)O[C@@H]2[C@H]([C@@H]([C@@H](COC(C3=CC(O)=C(O)C(O)=C3)=O)O[C@H]2OC(C4=CC(O)=C(O)C(O)=C4)=O)O)OC(C5=CC(O)=C(O)C(O)=C5)=O
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Target
UGT
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Purity
99.08
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light)
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Shipping Conditions
Room Temperature
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1,2,3,6-Tetragalloylglucose [CAS 79886-50-3]
1,2,3,6-Tetragalloylglucose is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.