(10E,12Z) -Octadeca-10,12-dienoic acid [CAS 2420-56-6]
(10E,12Z) -Octadeca-10,12-dienoic acid [CAS 2420-56-6]
SKU:QM-0138924-01
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Product Details
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Description
(10E,12Z) -Octadeca-10,12-dienoic acid (trans-10, cis-12 CLA2) is an orally active PPARα activator and inhibits adipocyte differentiation. (10E,12Z) -Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. (10E,12Z) -Octadeca-10,12-dienoic acid can induce proinflammatory cytokines and chemokines, which would lead to decreased adipogenesis and insulin resistance in adipose tissue. (10E,12Z) -Octadeca-10,12-dienoic acid can affect many aspects of milk fat synthesis. (10E,12Z) -Octadeca-10,12-dienoic acid reduces expression of lipogenic enzymes and inhibits the desaturation of fatty acids. (10E,12Z) -Octadeca-10,12-dienoic acid can reduce lipoprotein lipase (LPL) activity in cultured 3T3-L1 adipocytes and enhance triacylglycerol release from these cells. (10E,12Z) -Octadeca-10,12-dienoic acid decreases the expression of hepatic stearoyl-CoA desatyrase mRNA in mice. (10E,12Z) -Octadeca-10,12-dienoic acid is associated with changes in mucosal NF-κB and Cyclin D1 protein levels in mice[1][2][3][4][5][6].
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CAS Number
[2420-56-6]
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Molecular Formula
C18H32O2
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Molecular Weight
280.45
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Smiles
CCCCC/C=C\C=C\CCCCCCCCC(O)=O
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Target
Endogenous Metabolite; Lipase; NF-κB; PPAR; Stearoyl-CoA Desaturase (SCD)
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Isoform
PPARα
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Concentration
89.14 mM * 400 μL in Ethanol
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Purity
99.1
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Solubility
DMSO : ≥ 50 mg/mL
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Storage Conditions
Solution, -20°C, 2 years
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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(10E,12Z) -Octadeca-10,12-dienoic acid [CAS 2420-56-6]
(10E,12Z) -Octadeca-10,12-dienoic acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.