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γ-Secretase modulator 11 (hydrochloride) [CAS 2434630-30-3]
γ-Secretase modulator 11 (hydrochloride) [CAS 2434630-30-3]
SKU:QM-0067514
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Product Details
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Description
γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease[1].
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CAS Number
[2434630-30-3]
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Molecular Formula
C28H23ClF2N4O2
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Molecular Weight
520.96
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Smiles
O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=C(F)C=C5)C=C4F)=CC=CN32)C=C1)NC.[H]Cl
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Target
γ-secretase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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γ-Secretase modulator 11 (hydrochloride) [CAS 2434630-30-3]
γ-Secretase modulator 11 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.