1400W (Dihydrochloride) [CAS 214358-33-5]
1400W (Dihydrochloride) [CAS 214358-33-5]
SKU:QM-0155110-01
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Product Details
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Description
1400W dihydrochloride is the dihydrochloride form of 1400W. 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation[1][2].
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CAS Number
[214358-33-5]
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Molecular Formula
C10H17Cl2N3
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Molecular Weight
250.17
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Smiles
CC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl
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Target
Apoptosis; NO Synthase
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Isoform
INOS
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Purity
99.94
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Solubility
DMSO : 20 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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1400W (Dihydrochloride) [CAS 214358-33-5]
1400W (Dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.