1 1

17-Phenyl trinor PGF2α isopropyl ester [CAS 130209-76-6]

17-Phenyl trinor PGF2α isopropyl ester [CAS 130209-76-6]

Size

QM-0138834-01

£94.75 GBP
Sale Sold out

Request quote or documents

View full details

Product Details

  • Description

    17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.1 The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost.2 This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.3 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative is examined for IOP-lowering activity during the development of latanoprost.4 At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester is the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative is also significantly more irritating to the eye than latanoprost.

  • CAS Number

    [130209-76-6]

  • Molecular Formula

    C26H38O5

  • Molecular Weight

    430.58

  • Smiles

    O=C(OC(C)C)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C[C@@H]1O

  • Target

    Prostaglandin Receptor

  • Concentration

    10mM

  • Purity

    99.76

  • Solubility

    DMSO : ≥ 100 mg/mL

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302+H312+H332, H360

  • Precautions

    H302+H312+H332, H360
Learn more
Variant Variant total Quantity Price Variant total
1 mgQM-0138834-01
1 mgQM-0138834-01
£94.75/ea		 £0.00
£94.75/ea £0.00
5 mgQM-0138834-02
5 mgQM-0138834-02
£232.25/ea		 £0.00
£232.25/ea £0.00
10 mgQM-0138834-03
10 mgQM-0138834-03
£345.25/ea		 £0.00
£345.25/ea £0.00
25 mgQM-0138834-04
25 mgQM-0138834-04
£640.49/ea		 £0.00
£640.49/ea £0.00
50 mgQM-0138834-05
50 mgQM-0138834-05
£991.63/ea		 £0.00
£991.63/ea £0.00
100 mgQM-0138834-06
100 mgQM-0138834-06
£1,556.60/ea		 £0.00
£1,556.60/ea £0.00
View cart
0

Total items

£0.00

Product subtotal

Taxes, discounts and shipping calculated at checkout.
View cart

Related Products

Other industry favorites

17-Phenyl trinor PGF2α isopropyl ester [CAS 130209-76-6]

17-Phenyl trinor PGF2α isopropyl ester is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.