2-Acetamidophenol-d3 [CAS 122258-87-1]
2-Acetamidophenol-d3 [CAS 122258-87-1]
SKU:QM-0048497-01
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Product Details
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Description
2-Acetamidophenol-d3 (Orthocetamol-d3) is the deuterium labeled 2-Acetamidophenol. 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation[1][2].
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CAS Number
[122258-87-1]
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Molecular Formula
C8H6D3NO2
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Molecular Weight
154.18
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Smiles
OC1=C(NC(C([2H])([2H])[2H])=O)C=CC=C1
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Target
Ferroptosis; Glutathione Peroxidase; Isotope-Labeled Compounds; LDLR; Reactive Oxygen Species (ROS)
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Isoform
GPX4
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Shipping Conditions
Room temperature
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2-Acetamidophenol-d3 [CAS 122258-87-1]
2-Acetamidophenol-d3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.