2-Hydroxyisobutyric acid [CAS 594-61-6]
2-Hydroxyisobutyric acid [CAS 594-61-6]
SKU:QM-0191870-01
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Product Details
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Description
2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].
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CAS Number
[594-61-6]
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Molecular Formula
C4H8O3
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Molecular Weight
104.11
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Smiles
CC(C)(O)C(O)=O
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Target
Endogenous Metabolite
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Purity
99.57
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Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H318, H335
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Precautions
H315, H318, H335
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2-Hydroxyisobutyric acid [CAS 594-61-6]
2-Hydroxyisobutyric acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.