2-Methoxyestradiol-13C, d3 [CAS 1217470-09-1]
2-Methoxyestradiol-13C, d3 [CAS 1217470-09-1]
SKU:QM-0139882-01
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Product Details
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Description
2-Methoxyestradiol-13C, d3 is the 13C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].
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CAS Number
[1217470-09-1]
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Molecular Formula
C18 13CH23D3O3
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Molecular Weight
306.42
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Smiles
C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(O[13C]([2H])([2H])[2H])=C(O)C=C4CC3
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Target
Apoptosis; Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; Microtubule/Tubulin; Reactive Oxygen Species (ROS)
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H301+H311+H331-H315-H319-H335-H350-H360
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P403+P233-P405-P501
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2-Methoxyestradiol-13C, d3 [CAS 1217470-09-1]
2-Methoxyestradiol-13C, d3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.