3-Fluoro-evodiamine glucose
3-Fluoro-evodiamine glucose
SKU:QM-0124415
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Product Details
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Description
3-Fluoro-evodiamine glucose (Compound 8) is an evodiamine-glucose conjugate. 3-Fluoro-evodiamine glucose activates the expression of glucose transporter 1 (GLUT1), and inhibits topoisomerase I/II. 3-Fluoro-evodiamine glucose induces apoptosis and arrests the cell cycle at G2/M phase. 3-Fluoro-evodiamine glucose exhibits antitumor efficacy in vivo and in vitro, without significant toxicity[1].
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Molecular Formula
C25H26FN3O7
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Molecular Weight
499.49
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Smiles
O[C@H]1[C@@H]([C@H]([C@@H](O[C@@H]1CO)OC2=CC3=C(NC4=C3CCN5[C@]4([H])N(C6=C(C5=O)C=C(F)C=C6)C)C=C2)O)O
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Target
Apoptosis; GLUT; Topoisomerase
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Isoform
GLUT1; Topo I; Topo II
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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3-Fluoro-evodiamine glucose
3-Fluoro-evodiamine glucose is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.