(3R,5R) -Rosuvastatin [CAS 1094100-06-7]
(3R,5R) -Rosuvastatin [CAS 1094100-06-7]
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Product Details
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Description
(3R,5R) -Rosuvastatin is the (3R,5R) -enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM[2]. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[3].
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CAS Number
[1094100-06-7]
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Molecular Formula
C22H28FN3O6S
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Molecular Weight
481.54
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Smiles
O=C(O)C[C@H](O)C[C@@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2
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Target
Autophagy; HMG-CoA Reductase (HMGCR) ; Potassium Channel
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H312-H332
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
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(3R,5R) -Rosuvastatin [CAS 1094100-06-7]
(3R,5R) -Rosuvastatin is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.