(3S) -Tanzisertib (hydrochloride) [CAS 2517855-91-1]
(3S) -Tanzisertib (hydrochloride) [CAS 2517855-91-1]
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Product Details
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Description
(3S) -Tanzisertib (hydrochloride) ((3S) -CC-930 (hydrochloride) ) is an orally active JNK inhibitor (IC50 values for JNK1, JNK2, and JNK3 are 61, 7, and 6 nM, respectively) . (3S) -Tanzisertib (hydrochloride) selectively inhibits ERK1, p38α, and EGFR (IC50 = 0.48, 3.4, and 0.38 μM, respectively) . (3S) -Tanzisertib (hydrochloride) inhibits LPS-induced TNFα production in an acute rat PK-PD model. (3S) -Tanzisertib (hydrochloride) can be used in idiopathic pulmonary fibrosis (IPF) research[1].
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CAS Number
[2517855-91-1]
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Molecular Formula
C21H24ClF3N6O2
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Molecular Weight
484.9
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Smiles
OC(CC1)CCC1NC2=NC=C3C(N([C@H]4CCOC4)C(NC5=C(C=C(C=C5F)F)F)=N3)=N2.Cl
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Target
EGFR; ERK; JNK; p38 MAPK; TNF Receptor
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Isoform
ERK1; JNK1; JNK2; JNK3; p38α
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Shipping Conditions
Room temperature
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(3S) -Tanzisertib (hydrochloride) [CAS 2517855-91-1]
(3S) -Tanzisertib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.