4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid-glu (PEG24-Me) -val-cit-NH-benzyloxyformic acid-MMAE
4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid-glu (PEG24-Me) -val-cit-NH-benzyloxyformic acid-MMAE
SKU:QM-0015075-01
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Product Details
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Description
4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid-glu (PEG24-Me) -val-cit-NH-benzyloxyformic acid-MMAE is a drug-linker conjugate for ADC. 4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid-glu (PEG24-Me) -val-cit-NH-benzyloxyformic acid-MMAE contains a linker and bioactive small molecule toxins MMAE. 4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid-glu (PEG24-Me) -val-cit-NH-benzyloxyformic acid-MMAE can conjugate with NN2101 (HY-P991293) (anti c-Kit) for synthesizing NN3201. NN3201 rapidly internalizes and inhibits SCF-driven signaling, thereby delivering its payload to induce cell cycle arrest and apoptosis. NN3201 exhibits significant c-Kit-dependent anti-tumor efficacies in various tumor models, such as small cell lung cancer (SCLC) and gastrointestinal stromal tumor (GIST).
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Molecular Formula
C138H223N11O44S2
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Molecular Weight
2804.42
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Smiles
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC([C@@H](NC(C(C=C1)=CC=C1C(C(CS(C2=CC=C(C)C=C2)(=O)=O)CS(C3=CC=C(C=C3)C)(=O)=O)=O)=O)CCC(N[C@@H](C(C)C)C(C[C@@H](CCCNC(N)=O)C(NC(C=C4)=CC=C4COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@]([C@H](CC)C)([C@H](OC)CC(N5[C@@H](CCC5)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C6=CC=CC=C6)=O)OC)=O)[H])=O)=O)=O)=O)=O)=O)=O
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Target
Apoptosis; Drug-Linker Conjugates for ADC; Microtubule/Tubulin
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Purity
97.88
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid-glu (PEG24-Me) -val-cit-NH-benzyloxyformic acid-MMAE
4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid-glu (PEG24-Me) -val-cit-NH-benzyloxyformic acid-MMAE is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.