4-hydroxy Nonenal Mercapturic Acid [CAS 146764-24-1]
4-hydroxy Nonenal Mercapturic Acid [CAS 146764-24-1]
SKU:QM-0127669
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Product Details
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Description
4-hydroxy Nonenal Mercapturic Acid (4-HNE) is generated by the peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid. 4-hydroxy Nonenal Mercapturic Acid is rapidly cleared from plasma and enters the enterohepatic circulation in rats as a glutathione conjugate. Approximately two-thirds of 4-hydroxy Nonenal Mercapturic Acid is excreted in the urine within 48 hours, primarily as mercapturic acid conjugates. Approximately half of the metabolites are C-1 aldehydes of 4-hydroxy Nonenal Mercapturic Acid that are reduced to alcohols. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form gamma-lactols and gamma-lactones, respectively, resulting in at least four or five final urinary metabolites of 4-HNE in vivo.
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CAS Number
[146764-24-1]
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Molecular Formula
C14H25NO5S
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Molecular Weight
319.42
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Smiles
OC1CC(SCC(NC(C)=O)C(O)=O)C(CCCCC)O1
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Target
Endogenous Metabolite
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Shipping Conditions
Room temperature
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Hazard Statement
H225-H319
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Precautions
P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235-P501
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4-hydroxy Nonenal Mercapturic Acid [CAS 146764-24-1]
4-hydroxy Nonenal Mercapturic Acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.