4-Methyl-2-oxopentanoic acid [CAS 816-66-0]
4-Methyl-2-oxopentanoic acid [CAS 816-66-0]
SKU:QM-0171563-01
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Product Details
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Description
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease[1][2][3][4][5].
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CAS Number
[816-66-0]
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Molecular Formula
C6H10O3
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Molecular Weight
130.14
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Smiles
CC(C)CC(C(O)=O)=O
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Target
Autophagy; Endogenous Metabolite; mTOR; SOD
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Isoform
Human Endogenous Metabolite
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Purity
99.51
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Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light)
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Shipping Conditions
Room Temperature
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Hazard Statement
H314
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Precautions
H314
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4-Methyl-2-oxopentanoic acid [CAS 816-66-0]
4-Methyl-2-oxopentanoic acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.