5,6,7,8-Tetrahydro-8-deazahomofolic acid [CAS 111113-75-8]
5,6,7,8-Tetrahydro-8-deazahomofolic acid [CAS 111113-75-8]
SKU:QM-0004283
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Product Details
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Description
5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase[1].
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CAS Number
[111113-75-8]
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Molecular Formula
C21H26N6O6
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Molecular Weight
458.47
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Smiles
O=C1C2=C(NC(N)=N1)CC[C@@H](N2)CCNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O
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Target
DNA/RNA Synthesis
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Shipping Conditions
Room temperature
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5,6,7,8-Tetrahydro-8-deazahomofolic acid [CAS 111113-75-8]
5,6,7,8-Tetrahydro-8-deazahomofolic acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.