5,6-Epoxyeicosatrienoic acid-d11 [CAS 1881277-30-0]

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SKU:QM-0128581

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Description
5,6-Epoxyeicosatrienoic acid-d11 (5,6-EET-d11) is deuterium labeled 5,6-Epoxyeicosatrienoic acid. 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±) 5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±) 5,6-Epoxyeicosatrienoic acid is provided as a mixture of the free acid and lactone[1].
CAS Number
[1881277-30-0]
Molecular Formula
C20H21D11O3
Molecular Weight
331.53
Smiles
[2H]C([2H])(C([2H])(C([2H])(/C=C\C/C=C\C/C=C\C[C@H]1O[C@H]1CCCC(O)=O)[2H])[2H])C([2H])(C([2H])([2H])[2H])[2H]
Target
Adrenergic Receptor; Isotope-Labeled Compounds
Shipping Conditions
Room temperature

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5,6-Epoxyeicosatrienoic acid-d11 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.