7,4'-Dihydroxyflavone (Standard) [CAS 2196-14-7]
7,4'-Dihydroxyflavone (Standard) [CAS 2196-14-7]
SKU:QM-0024241-01
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Product Details
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Description
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM) . 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex) ‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].
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CAS Number
[2196-14-7]
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Molecular Formula
C15H10O4
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Molecular Weight
254.24
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Smiles
O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC=C13
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Target
CCR; COX; NF-κB
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Shipping Conditions
Room temperature
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7,4'-Dihydroxyflavone (Standard) [CAS 2196-14-7]
7,4'-Dihydroxyflavone (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.