8,11,14-Eicosatriynoic acid [CAS 34262-64-1]
8,11,14-Eicosatriynoic acid [CAS 34262-64-1]
SKU:QM-0061732
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Product Details
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Description
8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX) and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization[1][2][3]. 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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CAS Number
[34262-64-1]
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Molecular Formula
C20H28O2
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Molecular Weight
300.44
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Smiles
CCCCCC#CCC#CCC#CCCCCCCC(O)=O
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Target
COX
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Solubility
10 mM in DMSO
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Storage Conditions
Store at room temperature 3 years
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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8,11,14-Eicosatriynoic acid [CAS 34262-64-1]
8,11,14-Eicosatriynoic acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.