A 62176 (hydrochloride) [CAS 111783-54-1]
A 62176 (hydrochloride) [CAS 111783-54-1]
SKU:QM-0086854
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Product Details
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Description
A 62176 hydrochloride is a compound that targets DNA topoisomerase II and has the activity of inhibiting purine synthesis in cancer cells. A 62176 hydrochloride interferes with c-MYC mRNA expression by interacting with G-quadruplex. The main mechanism of action of A 62176 hydrochloride is by displacing nucleosomes from the quadruplex of non-template strand rDNA, resulting in rapid redistribution of nucleosomes. The application potential of A 62176 hydrochloride is that it causes DNA damage and relies on BRCA1/2-mediated homologous recombination and DNA-PK-mediated non-homologous end-joining pathways to repair the damage[1].
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CAS Number
[111783-54-1]
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Molecular Formula
C20H17ClFN3O4
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Molecular Weight
417.82
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Smiles
O=C(C1=CN2C3=C(OC4=C2C(C1=O)=CC(F)=C4N5CCC(C5)N)C=CC=C3)O.Cl
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Target
Endogenous Metabolite
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Shipping Conditions
Room temperature
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A 62176 (hydrochloride) [CAS 111783-54-1]
A 62176 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.