ABS-752 (hydrochloride) [CAS 2922884-90-8]
ABS-752 (hydrochloride) [CAS 2922884-90-8]
SKU:QM-0055629
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Product Details
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Description
ABS-752 is an orally active prodrug of CRBN-modulating molecular glue targeting. ABS-752 can effectively degrade GSPT1. ABS-752 can degrade NEK7. ABS-752 does not form ternary complexes with CRBN and the neosubstrates. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002. ABS-752 can be used for the study of hepatocellular carcinoma (HCC) [1].
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CAS Number
[2922884-90-8]
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Molecular Formula
C14H15ClFN3O3
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Molecular Weight
327.74
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Smiles
O=C1C2=CC(F)=C(CN)C=C2CN1C3C(NC(CC3)=O)=O.Cl
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Target
Molecular Glues; NEKs
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Isoform
NEK7
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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ABS-752 (hydrochloride) [CAS 2922884-90-8]
ABS-752 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.