ABT-751 (Standard) [CAS 141430-65-1]
ABT-751 (Standard) [CAS 141430-65-1]
SKU:QM-0005897-01
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Product Details
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Description
ABT-751 (Standard) is the analytical standard of ABT-751. This product is intended for research and analytical applications. ABT-751 (E7010) is a novel, highly orally bioavailable sulfonamides antimitotic compound and tubulin binder. It prevents tubulin aggregation by binding to the colchicine site on β-tubulin, leading to cell cycle arrest in G2/M phase and inducing apoptosis, thus effectively preventing cell division. ABT-751 induces autophagy by inhibiting the AKT/MTOR signaling pathway. ABT-751 showed significant inhibition against various types of cancer cells, including lung, gastric, colon, and breast cancer[1][2][3][4][5][6][7][8].
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CAS Number
[141430-65-1]
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Molecular Formula
C18H17N3O4S
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Molecular Weight
371.41
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Smiles
COC1=CC=C(C=C1)S(=O)(NC2=C(N=CC=C2)NC3=CC=C(C=C3)O)=O
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Target
Apoptosis; Autophagy; Microtubule/Tubulin; Reference Standards
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Shipping Conditions
Room temperature
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ABT-751 (Standard) [CAS 141430-65-1]
ABT-751 (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.